Metofur

Powder for Oral Use

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DESCRIPTION:

Powder from light yellow to yellow-brown color, odorless.

COMPOSITION :

1 g of the drug contains active substances (mg):

Metronidazole – 110;

Oxytetracycline hydrochloride 25;

Furazolidon 65.

Excipients: up to 1 g.

PHARMACOLOGICAL CHARACTERISTICS:

Metofur is a complex drug with a wide range of bactericidal and bacteriostatic actions.

Metronidazole belongs to a 5-nitroimidazole group. Its mechanism of action is the biochemical restoration of the 5-nitroimidazole group by intracellular transport proteins of anaerobic bacteria and protozoa. Restored 5-nitro group of metronidazole interacts with the DNA of microbial cells by inhibiting the synthesis of nucleic acids, leading to the death of the microorganism. Effective against protozoa (Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica), obligate anaerobic bacteria (Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides vulgatus), some gram-positive bacteria (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.).

Oxytetracycline hydrochloride is a bacteriostatic antibiotic which mechanism of action provides violation of protein synthesis during its interaction with ribosomes and provides reduction of the permeability of the cytoplasmic membrane of susceptible microorganisms. The drug has a broad spectrum of activity against gram-positive and gram-negative microorganisms: Streptococcus spp., Clostridium spp., Corynebacterium spp., Brucella spp., Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Erysipelothrix spp., Fusobacterium spp. , Salmonella spp., and protozoa (Protozoa), mycoplasma (Mycoplasma spp.), rickettsia (Rickettsia spp.), and chlamydia (Chlamydia).

Furazolidone is a synthetic antibacterial and antiprotozoal drug, a derivative of nitrofuran. It blocks the enzyme system of bacteria sensitive to it. Furazolidone is active against Giardia, Vibrio cholera, Trichomonas, Coccidia, as well as E. Coli, Enterobacter spp., Campylobacter spp., Salmonella spp.

APPLICATION:

Dogs, Cats: treatment of gastrointestinal diseases and prevention of surgical complications caused by microorganisms sensitive to components of the drug.

Fur animals (minks, foxes): prevention and treatment of coccidiosis and diseases of the gastrointestinal tract, caused by pathogens susceptible to components of the drug.

Fancy pigeons: prevention and treatment of blackhead, coccidiosis, salmonellosis, trichomoniasis, caused by microorganisms sensitive to components of the drug.

DOSAGE:

Orally with feed, at doses:

Dogs, cats: the therapeutic dose is 0.1-0.2 g product per 1 kg body weight 3 times a day for 7-10 days.

Fur animals (minks, foxes): the therapeutic dose is 0.2- 0.3 g product per 1 kg body weight 3 times a day for 3-5 days;

The prophylactic dose for calves during the weaning is 1.0-1.5 grams of the drug on 10 goals for 2 weeks.

Fancy pigeons: the therapeutic dose of 3 g per 1 kg of feed daily for 7-10 days; Prophylactic dose – 1 g drug per 1 kg of feed daily for 2 weeks

CONTRAINDICATIONS:

Hypersensitivity to the components of the drug.

Do not use to food-producing animals.

PRECAUTIONS:

Repeat the treatment after a 10-day break.

Use with caution to animals with impaired renal and liver function.

PACKAGING:

Packages made of a polymeric film, foil laminated packages 20,50, 100, 200, 500, 1000 g.

STORAGE:

Dry, dark, unreachable for children place at a temperature from 2°C to 20°C.

Store the medicine separately from food, drinks, including the animal feed.

FOR VETERINARY USE ONLY!

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