Solution of Vitamins A, D3, E, F in Oil for Injection
DESCRIPTION:
Transparent oily liquid from light yellow to light brown color odorless.
COMPOSITION:
Contains per ml:
Vitamin A, Retinol-Palmitate…………. 20 000 IU.
Vitamin D₃, cholecalciferol ……………. 6000 IU.
Vitamin E, α-tocopherol acetate………… 60 mg.
Solvents ad……………………………………… 1 ml.
PHARMACOLOGICAL CHARACTERISTICS:
Vitamin A belongs to the fat-soluble vitamins that participate in redox processes in carbohydrate and fat metabolism effects on mineral and hormonal exchanges.
The mechanism of action of vitamin A provides regulation of oxygen uptake in biochemical processes; inhibition of insulin activity and strengthening of conversion of carbohydrates to proteins in the liver; activation of the metabolism of calcium and magnesium providing formation of the skeleton; slowing of formation of keratohyalin granules in the lipid layer of cell membranes and maintaining of elasticity of cell membranes; ensuring of normal function of organs of vision, skin, respiratory tract, alimentary canal, reproductive system.
Vitamin A plays an important role in the interaction of proteins with lipids in cell membranes, providing their functioning and regulates the permeability.
Most sensitive to vitamin A deficiency are lysosomal membranes, in case of its lack is increased elimination of their enzymes. Structural violations of mitochondria membranes in hepatocytes leads to disorders of breathing and phosphorylation process.
Lack of vitamin A in animal organisms increases free radical oxidation; in animal tissues is disturbed biosynthesis of proteins, changing their electrophoretic properties. Also, vitamin A provides the normal functioning of the reproductive functions of animals: sperm- and oogenesis, development and growth of embryos, the early onset of puberty, the synthesis of sex hormones.
Vitamin D3 belongs to a group of fat-soluble vitamins, affects the metabolism of calcium and phosphorus, beginning from its absorption in the gut and ending with removal from the body.
Promotes the formation of bone tissues during the growth period, in case of treatment of rickets, osteomalacia, bone fractures. Regulates calcium and phosphorus content in the blood and bone tissue, provides a physiological ratio of them in the body.
Vitamin E belongs to a group of fat-soluble vitamins and plays an important role as a regulator of lipid biosynthesis of protein; increases levels of myosin and actomyosin; provides ATP metabolism; prevents oxidation of fats, fatty acids, and sterols, delaying oxidation of fats; prevents the formation of toxic metabolites; slows the metabolism of carbohydrates, proteins, nucleic acids, and steroids, and provides resistance of erythrocytes to hemolysis and oxidation.
Vitamin E provides a structure of cell membranes and intracellular inclusions, which provides lysosomal stability and delays exiting from them lysosomal hydrolytic enzymes and prevents their participation in the development of dystrophy in case of the white-muscle disease.
The effect of vitamin E on the membrane structures positively effects on stability and functional activity of the surface epithelium of the mucous membranes of the digestive canal, uterus, conjunctiva.
Vitamin E ensures the normal functioning of the digestive and reproductive apparatus. Helps males to regulate spermatogenesis and reduces the number of pathologically changed spermatozoa and prevents degeneration of the epithelium of seminiferous tubules.
Vitamin E helps females to contribute to the attachment of the embryo to the uterus and fetal development.
Vitamin F lowers the content of cholesterol in the blood, helps to normalize blood coagulation processes, participates in lipid metabolism, increases the level of albumin. In case of lack of vitamin F in animal, the organism is observed increase of cholesterol and beta-globulins in blood, reduction of the level of albumin, and in chronic cases animals have dermatitis
APPLICATION:
Drug use for prevention and treatment of A- and D-vitamin deficiencies, nutritional and secondary osteodystrophy of farm animals and for their treatment in case of postpartum hypocalcemia and hypophosphatemia, pre-and postnatal bed sores, bronchitis and pneumonia, white-muscle disease, fractures, delay of the placenta, endometritis, subinvolution of uterus. Also, the drug is effective for the prevention of urolithiasis, during transportation, changing diet, stress, after surgical interventions, and trauma.
DOSAGE:
The drug with a preventive purpose is administered intramuscularly or subcutaneously once every 7-10 days for therapeutic purposes IM once every 5 days up to recovery (5-8 injections).
In the future (if necessary) drug is injected at prophylactic doses.
Orally drug is applied every day at specified prophylactic doses.
Doses of the drug are calculated by vitamin A.
| TYPE OF ANIMAL | PARENTERALLY, DOSE, ML | PARENTERALLY, DOSE, ML | Orally DOSE ML /day |
| PREVENTIVE | THERAPEUTIC | ||
| Non milking cows | 10 | 10 | 1.5 |
| Milch cows | 10-12 | 10-12 | 2.5 |
| Young cattle (per 100 kg of body weight) | 2,5-3,0 | 2,5-3,0 | 0,5-0,4 |
| Sows (second half of gestation) | 3,0 | 3,0 | 0,4 |
| Lactating sows | 4.0 | 5.0 | 0.6 |
| Piglets (20-30 kg) | 1.0 | 1,0-1,5 | 0,1-0,12 |
| Mares in foal | 7.0 | 10,0 | 0,6-0,7 |
| Lactating mares | 8.0 | 12.0 | 0,7-0,8 |
| Foals aged 12-6 months. | 2.0 | 3.0 | 0.3 |
CONTRAINDICATIONS:
Not established.
PRECAUTIONS:
The drug is necessary to balance the diet of animals with protein, calcium, phosphorus, magnesium, and trace elements.
PACKAGING:
100 ml bottles made of dark glass, closed with rubber plugs and aluminum caps.
STORAGE:
Dry, dark place at temperature from 5°C to 15°C.
FOR VETERINARY USE ONLY!