Solution for Injection
DESCRIPTION:
Clear thick yellow solution.
COMPOSITION :
1 ml contains: Closantel – 50 mg;
PHARMACOLOGICAL CHARACTERISTICS:
The active ingredient of the drug – closantel, antiparasitic agent, structurally derived salicylanilide that has a long effect on endo- and ectoparasites.
Closantel blocks the phosphorylation process (formation of ATP) in the body of parasites through interference in the process of transporting electrons, changing energy metabolism, resulting in the death of parasites.
Closantel has a wide range of actions, effective in the treatment of parasitic diseases of cattle and small ruminants caused by nematodes, trematodes, and arthropods.
Closantel is rapidly absorbed after oral or intramuscular administration.
Blood sheep concentration reached Maximum after 8-24 hours of administration.
Blood cattle concentration reached Maximum after 24-48 hours of administration.
The half-decomposition is approximately 12-15 days.
Most of all closantel is concentrated in the lungs and kidneys, and the main way of its metabolism is renewable deionization.
APPLICATION:
Prevention and treatment of cattle and small ruminants from the following diseases:
Cattle:
- Fasciolosis (Fasciola hepatica, mature and late larval forms);
- Nematodiasis (adult and larval forms Bunostomum spp., Haemonchus contortus, Haemonchus placei, and Oesophagostomum radiatum);- hypodermosis caused by the larvae of subcutaneous gadfly Hypoderma spp.; sheep, goats:
- Fasciolosis (Fasciola hepatica, mature and late larval forms);
- Nematodiasis (adult and larval forms Bunostomum spp., Haemonchus contortus, Haemonchus placei, and Oesophagostomum radiatum, hypodermosis caused by the larvae of subcutaneous gadfly Hypoderma spp.;
- Sheep, goats:
- Fasciolosis (Fasciola hepatica, mature and late larval forms);
- Nematodiasis (adult and larval forms Bunostomum spp., Haemonchus сontortus, Haemonchus placei and Oesophagostomum radiatum, Chabertia ovina);
- Oestrosis (Oestrosis ovis).
DOSAGE:
The drug is administered subcutaneously once at the following doses given in the table.
| TYPE ANIMALS | DISEASES | THE DOSE BY THE ACTIVE SUBSTANCE | DOSE |
| Cattle | Fasciolosis Nematodiasis Hypodermosis | 2,5 mg closantel per kg of body weight. 2,5 mg closantel per kg of body weight. 5 mg closantel per kg of body weight | 0,5 ml/10 kg of body weight. 0,5 ml/10 kg of body weight. 1 ml/10 kg of body weight |
| Sheep, goats | Fasciolosis Nematodiasis, Oestrosis | 5 mg closantel per kg of body weight. 2,5 mg closantel per kg of body weight | 1 ml/10 kg of body weight. 0,5 ml/10 kg of body weight |
It is recommended to apply the dose in different places
CONTRAINDICATIONS:
Do not use it in conjunction with antiparasitic chlorine-organic products.
Do not use it for dairy cows and pregnant females in the last trimester of pregnancy.
PRECAUTIONS:
Meat consumption is after 28 days from the last dose.
Milk consumption is after 14 days from the last dose.
Slight inflammation in the injection site is possible, but it will disappear independently in 2-3 days after injection.
Some breeds of cattle (Charolais and its hybrids) are particularly sensitive to the drug, approximately 2% of the animals had anaphylactic reactions after the injection.
PACKAGING :
Glass bottles of 50, 100 and 250 ml.
Bottles sealed with a gray rubber stopper, with an aluminum cap on top.
STORAGE:
Store in a cool, dry, dark place at the temperature from 5°C to 25°C.
FOR VETERINARY USE ONLY!