COMPOSITION :
1 ml contains: Closantel – 50 mg;
PHARMACOLOGICAL CHARACTERISTICS:
Closantel, the active ingredient, is an antiparasitic agent derived from salicylanilide, with prolonged effects on endo- and ectoparasites. It disrupts the phosphorylation process in parasites, interfering with electron transport and altering energy metabolism, ultimately leading to parasite death. Effective against a wide range of parasitic diseases in cattle and small ruminants caused by nematodes, trematodes, and arthropods. Rapidly absorbed after oral or intramuscular administration, reaching peak blood concentrations in sheep after 8-24 hours and in cattle after 24-48 hours, with a half-life of approximately 12-15 days. Mainly concentrated in the lungs and kidneys, metabolized through renewable deionization.
APPLICATION:
This medication is used for the prevention and treatment of cattle and small ruminants affected by various diseases including fasciolosis, nematodiasis, and oestrosis.
DOSAGE:
Administered subcutaneously once at recommended doses, with the suggestion to apply the dose in different locations.
| TYPE ANIMALS | DISEASES | THE DOSE BY THE ACTIVE SUBSTANCE | DOSE |
| Cattle | Fasciolosis Nematodiasis Hypodermosis | 2,5 mg closantel per kg of body weight. 2,5 mg closantel per kg of body weight. 5 mg closantel per kg of body weight | 0,5 ml/10 kg of body weight. 0,5 ml/10 kg of body weight. 1 ml/10 kg of body weight |
| Sheep, goats | Fasciolosis Nematodiasis, Oestrosis | 5 mg closantel per kg of body weight. 2,5 mg closantel per kg of body weight | 1 ml/10 kg of body weight. 0,5 ml/10 kg of body weight |
CONTRAINDICATIONS:
Avoid concurrent use with chlorinated antiparasitic products. Not suitable for dairy cows and pregnant females in the last trimester of pregnancy.
PRECAUTIONS:
Meat consumption permissible after 28 days from the last dose, while milk consumption is permissible after 14 days. Minor inflammation at the injection site may occur, typically resolving within 2-3 days. Some cattle breeds, notably Charolais and hybrids, may be sensitive to the drug, with approximately 2% experiencing anaphylactic reactions post-injection.
PACKAGING :
Available in glass bottles of 50, 100, and 250 ml.
STORAGE:
Store in a cool, dry, dark place at temperatures between 5°C to 25°C.
FOR VETERINARY USE ONLY!