Powder for Injection
DESCRIPTION:
A Homogeneous powder of light yellow color with a weak specific smell
COMPOSITION:
1 ml contains active substances:
Sulfadimethoxine sodium salt – 300 mg;
Sulfadiazine sodium salt – 300 mg;
Trimethoprim – 120 mg.
PHARMACOLOGICAL CHARACTERISTICS:
The mechanism of action of the drug that contains sulfonamides and trimethoprim provides blocking of two successive stages of the biosynthesis of folic acid in the bacterial cell. This leads to inhibition of bacterial growth, propagation, and termination of their death.
The combination of two sulfonamides and original diaminopyrimidine (trimethoprim) provides a synergistic effect that extends the antimicrobial spectrum of activity against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Neisseria spp., Clostridium spp., Listeria monocytogenes, Corynebacterium spp., E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Citrobacter spp., Pasteurella spp., Bordetella spp, Enterobacter spp., Yersinia enterocolitica, chlamydia spp., Vibrio cholera, etc.). Some protozoa are also sensitive to components of the drug (Pneumocystis carinii, Coccidia, and Toxoplasma). This combination of sulfonamides and trimethoprim reduces the probability of resistant strains of pathogenic organisms
APPLICATION:
Treatment of cattle, sheep, goats, horses, pigs, rabbits, dogs, cats, and poultry (chickens, turkeys, ducks, geese) diseases of the gastrointestinal tract (gastritis, enteritis, dyspepsia), respiratory (tonsillitis, tracheitis, pharyngitis, bronchopneumonia, pleurisy) and genitourinary (postpartum sepsis, cystitis, urethritis, endometritis), postoperative complications, mastitis, actinomycosis, erysipelas, dysentery, diplococcus, enterotoxemia, coccidiosis, colibacillosis, strangles, pasteurellosis, pullorosis, oedema, mycoplasmosis, salmonellosis, caused by pathogens susceptible to sulfadimethoxine, sulfadiazine and trimethoprim.
DOSAGE:
Injected as Intramuscularly at doses:
Cattle, Sheep, Goats, Horses, Pigs – 0.6-0.8 ml per 10 kg of body weight;
Dogs, Cats – 0.1-0.15 ml per 1 kg of body weight;
Poultry (Chickens, Turkeys, Ducks, Geese), Rabbits – 0.1 ml per 1 kg of body weight.
Repeated application is carried out 3-5 times at intervals of 24-36 hours.
The recommended course of treatment is 5 days.
In cases of incomplete disappearance of clinical signs extend the application period for 2 days.
For large animals is allowed slow intravenous injection or intra-arterial injection.
For the treatment of young poultry, pigs and rabbits are allowed application with the drinking water. In this case solution of the drug add to the daily requirement of drinking water at a rate of 1 ml per 0,9-1,2 liters of drinking water (1 g of powder per 3 liters of water).
In one place the injection to young and small animals should be given no more than 10 ml, and to adult animals – not more than 20 ml of the drug.
PRECAUTIONS:
To dilute the drug, do not use a solution of novocaine.
Goats have hypersensitivity to sulfonamides therefore a solution of the drug should be used with caution.
Meat consumption is allowed in 10 days.
Milk consumption and eggs are allowed in 4 days after the last application of the drug.
Received by the deadline meat, milk, and eggs fed to unproductive animals or utilize, according to a conclusion of the doctor of veterinary medicine.
PACKAGING :
Glass bottles closed with a rubber plug under an aluminum cap, 3.3 and 6.6 g complete with sterile 0.9% sodium chloride of 8 and 16 respectively.
STORAGE:
Dry, dark, unreachable for children place at a temperature from 0°C to 25°C
After making the solvent resulting solution should be used during the day and if it provided with cold storage – within three days after preparation.
FOR VETERINARY USE ONLY!