PENTATAB 5

Antibacterial Agent

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DESCRIPTION:

Cylindrical tablets with a flat surface, scored and beveled, from light yellow to yellow (on the surface of tablets allowed marbling-inclusions).

COMPOSITION:

1 tablet (0.8 g product) contains active substances:

Sulfadimine – 70 mg;

Oxytetracycline hydrochloride – 45 mg;

Trimethoprim – 30 mg;

Tylosin tartrate – 25 mg;

Norsulfazole – 80 mg.

PHARMACOLOGICAL CHARACTERISTICS:

Pentatab 5 tablets is a complex drug with a broad spectrum of bactericidal and bacteriostatic actions. Sulfadimine is active against gram-positive and gram-negative bacteria: E. coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii. The mechanism of action is associated with PABA and competitive inhibition of dihydropteroate synthetase, leading to disruption of synthesis of tetrahydrofolic acid required for the synthesis of purines and pyrimidines.

Oxytetracycline is a bacteriostatic antibiotic their mechanism of action that provides violation of protein synthesis during its interaction with ribosomes and reduction of the permeability of the cytoplasmic membrane of susceptible microorganisms. The drug has a wide range of effects on gram-positive and gram-negative microorganisms: Streptococcus spp., Clostridium spp., Corynebacterium spp., Brucella spp., Haemophilus spp., E. coli, Pasteurella spp., Klebsiella spp., Erysipelothrix spp., Fusobacterium spp. , Salmonella spp., as well as protozoa (Protozoa), mycoplasma (Mycoplasma spp.), rickettsia (Rickettsia spp.), and chlamydia (Chlamydia).

Trimethoprim is a chemotherapeutic drug, which has a bactericidal action against gram-positive (Staphylococcus spp., Streptococcus spp., Clostridium spp., Corynebacterium spp., and others.) and gram-negative (E. coli, Salmonella spp., Klebsiella spp., Proteus spp., Pasteurella spp., Bordetella spp., etc.) microorganisms. The drug inhibits bacterial reductase, which converts dihydrofolate acid into tetrahydrofolic, which is essential for the synthesis of purines and nucleic acids. Thereby trimethoprim blocks one of the basic processes of metabolism of bacteria towards protein synthesis.

Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae, and includes mainly tylosin A. Tylosin effective against gram-positive and some gram-negative microorganisms: Corynebacterium spp., Clostridium spp., Erysipelothrix spp., Pasteurella spp., Vibrio spp., Leptospira spp., Brucella spp., Neisseria spp., Haemophilus spp., as well as against rickettsia (Rickettsia spp.), spirochetes (Spirochaeta (Borrelia anserina, Brachyspira hyodysenteriae)), and mycoplasma (M. gallisepticum, M. synoviae, M . meleagridis). Tylosin tartrate exhibits bacteriostatic effect by inhibition of protein synthesis (via an irreversible connection with bacterial 50S ribosome subunits) and microbial cell growth and reproduction.

APPLICATION:

CALVES: treatment of animals suffering from gastroenteritis, salmonellosis, pasteurellosis, campylobacteriosis, caused by microorganisms sensitive to components of the drug.

PIGS: treatment of animals suffering from enzootic pneumonia, arthritis, dysentery, edema disease, erysipelas, salmonellosis, pasteurellosis, caused by microorganisms sensitive to components of the drug.

SHEEP: treatment of animals suffering from septicemia, contagious agalactia, caused by microorganisms sensitive to components of the drug.

RABBITS: treatment of animals suffering from pasteurellosis, salmonellosis, and septicemia, caused by microorganisms sensitive to components of the drug.

POULTRY (CHICKEN (BROILERS), TURKEYS, GEESE, DUCKS): treatment of poultry, suffering from typhus, cholera, salmonellosis, mycoplasmosis, rhinitis, caused by microorganisms sensitive to components of the drug.

DOSAGE:

Orally with dry or wet feed individually or by group method, after crushing the tablets.

The daily dose for all types of animals is 0.8-1.2 g (1-1.5 tablets) per 10 kg of body weight, which is given in two divided doses. The first application of dose may be increased to twice (depending on severity).

The treatment lasts 3-5 days (until the disappearance of clinical symptoms). At relapse of disease, treatment is carried out at least three days before full recovery of animals.

During coccidiosis treatment lasts 2-3 courses at intervals between 5-7 days.

Mixtured drug with feed and fed to the animals during the day.

CONTRAINDICATIONS:

Do not apply to animals with hypersensitivity to the components of the drug, as well as with the liver and kidneys diseases.

Do not use to ruminants with functionally developed proventriculus and to laying hens, which eggs are used in food by people.

PRECAUTIONS:

Meat consumption is allowed after 8 days from the last application. Received, by the deadline, meat fed to unproductive animals or utilize, according to a conclusion of the doctor of veterinary medicine.

PACKAGING :

Blister package 10, 30, 100 tablets per carton.

STORAGE:

Dry, dark, unreachable for children place at a temperature from 4°C to 25°C.

Do not store it together with food, drinks, including animal feeds.

FOR VETERINARY USE ONLY!

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