PenStrep 450

Suspension for Injection



The suspension is white and homogeneous in case of shaking.


1 ml contains active substances:

Penicillin G procaine – 200 000 Units;

Dihydrostreptomycin sulfate – 250 mg;

Betamethasone – 0.5 mg;

Chlorpheniramine maleate – 8 mg;

Procaine hydrochloride – 15 mg;

Excipients up to 1 ml.


Penicillin G procaine is an antibiotic of the beta-lactam series, which has a broad spectrum of bactericidal activity against gram-positive and gram-negative microorganisms: Corynebacterium pyogenes, Erysipelothrix rhusiopathiae, Listeria spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus spp., Streptococcus spp. The mechanism of action of substance provides a violation of the synthesis of peptidoglycan – cell wall mucopeptide, that leads to inhibition of synthesis of the cell wall of microorganisms, inhibition of growth, and reproduction of bacteria.

Dihydrostreptomycin sulfate is an aminoglycoside antibiotic that has a bactericidal effect on gram-negative and gram-posi- tive bacteria (Escherichia coli, Salmonella spp., Shigella spp., Yersinia spp., Klebsiella spp., Haemophilus influenzae, Staphylococcus spp., Corynebacterium pyogenes). Bactericidal effect substance shows by binding with 308-subunit of the bacterial ribosome, which then leads to inhibition of protein synthesis.

Chlorpheniramine maleate acts as a desensitizing, antihistamines agent. It improves respiratory processes.

Betamethasone is a synthetic corticosteroid that has a strong anti-inflammatory effect.

Procaine hydrochloride is a local anesthetic, which exhibits analgesic and hypotensive actions. In the case of parenteral application, procaine hydrochloride reduces the production of acetylcholine, which reduces the excitability of peripheral cholinoceptive systems, contributes to the blocking effect on autonomic ganglias, reduces spasms of smooth muscles, reduces myocardial excitation and motor areas of the cerebral cortex.


Treatment of cattle, pigs, horses, sheep, goats, dogs, and cats suffering from omphalitis, arthritis, mastitis, septicemia and secondary infections, and diseases of the respiratory and urinary tract, caused by pathogens susceptible to penicillin and dihydrostreptomycin.


Injected as Intramuscularly at a dose of 1-1.5 ml per 10 kg of body weight for 3-4 days.

Cattle and Horses – 15-25 ml per animal per day;

Pigs – 10-12 ml per animal per day;

Dogs and Cats – 0.5-2 ml per animal per day.


Hypersensitivity to penicillins and dihydrostreptomycin.

Do not use on rabbits, guinea pigs, hamsters, and other small herbivores and animals with impaired renal function.


Possible manifestations of allergic reactions. Sometimes there are cases of short-term skin rashes, fever, vomiting, tremor, anxiety, and loss of coordination. Possible slight and transient reactions at the place of injection.


Meat consumption is allowed after 30 days from the last application.

Milk consumption is allowed in 3 days (6 milkings) after the last application.

Received by the deadline meat and milk, fed to unproductive animals or utilize, according to a conclusion of the doctor of veterinary medicine.


Bottles made of transparent brown hydrolytic glass closed with a rubber plug under an aluminum cap 100, and 250 ml.


Dry, dark, unreachable for children place at a temperature from 5°C to 25°C.