PenStrep 450



1 ml contains active substances:

Penicillin G procaine – 200 000 Units;

Dihydrostreptomycin sulfate – 250 mg;

Betamethasone – 0.5 mg;

Chlorpheniramine maleate – 8 mg;

Procaine hydrochloride – 15 mg;


Penicillin G procaine, an antibiotic of the beta-lactam series, exhibits broad-spectrum bactericidal activity against both gram-positive and gram-negative microorganisms, including Corynebacterium pyogenes, Erysipelothrix rhusiopathiae, Listeria spp., Pasteurella haemolytica, Pasteurella multocida, Staphylococcus spp., and Streptococcus spp. Its mechanism of action disrupts peptidoglycan synthesis, inhibiting cell wall formation and bacterial growth.

Dihydrostreptomycin sulfate, an aminoglycoside antibiotic, demonstrates bactericidal effects against a range of bacteria, including Escherichia coli, Salmonella spp., Shigella spp., Yersinia spp., Klebsiella spp., Haemophilus influenzae, Staphylococcus spp., and Corynebacterium pyogenes. It inhibits protein synthesis by binding to the 30S subunit of bacterial ribosomes.

Chlorpheniramine maleate acts as a desensitizing antihistamine, enhancing respiratory processes.

Betamethasone, a synthetic corticosteroid, exerts potent anti-inflammatory effects.

Procaine hydrochloride, a local anesthetic, provides analgesic and hypotensive actions by reducing acetylcholine production, thereby decreasing peripheral cholinoceptive system excitability, blocking autonomic ganglia, reducing smooth muscle spasms, and mitigating myocardial excitation and cerebral cortex motor area activity.


Used to treat omphalitis, arthritis, mastitis, septicemia, secondary infections, and respiratory and urinary tract diseases in cattle, pigs, horses, sheep, goats, dogs, and cats caused by pathogens susceptible to penicillin and dihydrostreptomycin.


Administered intramuscularly at a dose of 1-1.5 ml per 10 kg of body weight for 3-4 days.

Cattle and Horses: 15-25 ml per animal per day;

Pigs: 10-12 ml per animal per day;

Dogs and Cats: 0.5-2 ml per animal per day.


Avoid use in animals with hypersensitivity to penicillins and dihydrostreptomycin, as well as rabbits, guinea pigs, hamsters, and other small herbivores or those with impaired renal function.


Possible allergic reactions, transient skin rashes, fever, vomiting, tremors, anxiety, and loss of coordination. Transient reactions at the injection site may occur.


Meat consumption allowed after 30 days from the last application.

Milk consumption allowed after 3 days (6 milkings) from the last application.

Dispose of meat and milk according to the veterinarian’s recommendation.


Available in glass vial, 100 ml


Store in a dry, dark place inaccessible to children at temperatures from 5°C to 25°C.