Enroflox 100

Injection Solution

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DESCRIPTION:

A homogenous, transparent solution from light yellow to light brown color.

COMPOSITION:

1 ml of product contains an active agent:

Enrofloxacin – 100 mg.

CLINICAL PHARMACOLOGY:

The active ingredient of the drug – enrofloxacin, belongs to the fluoroquinolone group of antibiotics and has a broad spectrum of activity against gram-positive and gram-negative bacteria. Its mechanism of action is based on the inhibition of bacterial gyrase enzyme, leading to disruption of bacterial DNA replication.

Enrofloxacin exhibits bactericidal activity against the following microorganisms: E. coli, Pseudomonas spp., Salmonella spp., Campylobacter spp., Haemophilus spp., Pasteurella spp., Bordetella spp., Erysipelothrix rhusiopathiae, Klebsiella spp., Proteus spp., Vibrio parahaemolyticus, Staphylococcus aureus, Streptococcus spp., Clostridium perfringens, Actinobacillus spp., Fusobacterium spp., Enterococcus spp. and others, as well as the detrimental effect on mycoplasmas (Mycoplasma spp.) and chlamydia (Chlamydia spp.).

After injection enrofloxacin is rapidly and completely absorbed due to its high bioavailability. Its maximum blood concentration is reached after 6 hours, therapeutic concentration is maintained in 2 days.

Enrofloxacin is partially metabolized in the liver and is excreted with the urine and bile.
Enrofloxacin has a high level of distribution. Thus, concentrations in tissues and organs usually higher than in blood serum. The bodies, which can be observed the highest concentration – lungs, liver, kidneys, intestines.
The half-life period depends on the type of animal and reaches 2-7 hours.

APPLICATION:

Cattle: treatment of diseases of the gastrointestinal tract and respiratory system caused by microorganisms sensitive to enrofloxacin, secondary bacterial infections in viral diseases.

Pigs: treatment of diseases of the alimentary canal and respiratory system caused by microorganisms susceptible to enrofloxacin.

DOSAGE:

Cattle :(injected as SC )

2,5 ml/100 kg BWG (2,5 mg of enrofloxacin/1 kg BWG) once a day.

To treat animals with frequent respiratory infections and Salmonellosis, increase the dose by half. The duration of treatment is 3 days and in the case of Salmonellosis, is 5 days.

Pigs: (injected as IM )

2,5 ml/100 kg BWG (2,5 mg of enrofloxacin/1 kg BWG) once a day.

To treat animals with frequent respiratory infections and Salmonellosis, increase the dose by half. The duration of treatment is 3 days and in the case of Salmonellosis, is 5 days. In the case of Mastitis-metritis-agalactia syndrome, the course for the treatment is 1-2 days.

CONTRAINDICATIONS:

Do not apply to animals with hypersensitivity to enrofloxacin.

Do not apply the drug if found resistant strains of pathogenic bacteria resistant to quinolones.

Do not use in conjunction with antibiotics of the tetracycline group, chloramphenicol, macrolides, and cephalosporins.

Do not apply in the case of hypersensitivity to fluoroquinolones.

In combination with tetracycline, macrolides and chloramphenicol can appear antagonistic effects.

Do not apply to animals with central nervous system disorders,
kidney diseases, and disorders of cartilage growth.

Do not apply to horses.

PRECAUTIONS:

Product application must be stopped in the case of microorganisms’ resistibility to antibiotics. Biological DX confirmation and microorganisms resistibility susceptibility test as to antibiotic must be determined before product prescription.

If the animal does not resume its health in three days from treatment beginning, the product application must be replaced with another drug.

If the volume dose is more than 5 ml for cattle and 2.5 ml for pigs, it must be divided and injected into two different body parts.

Withdrawal :

Meat consumption is 10 days, and for milk is 7 days after the last product application.

Received before this time meat and milk must be fed to unproductive animals or utilized, depending on conclusion of veterinarian.

PACKAGING:

Brown glass bottles, closed by rubber plug under an aluminum cap 50 and 100 ml.

STORAGE:

Dry, dark, unreachable for children place at a temperature from 5°C to 25°C.

Store apart from food products, beverages, and animal feeds.

After the first taking, the product is usable for 28 days, storing as it original packing at a temperature from 5º to 25ºC.

FOR VETERINARY USE ONLY!

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