Injection Solution
DESCRIPTION:
Oil suspension from yellow to brown-yellow color with light substances odor, laminating during storing.
COMPOSITION:
1 ml of product contains API:
ceftiofur HCL – 50 mg;
ketoprofen – 150 mg.
CLINICAL PHARMACOLOGY:
Ceftiofur refers to cephalosporins of the third generation. It is effective against gram-positive and gram-negative bacteria, including strains, producing beta-lactamases and some anaerobic bacteria: Escherichia coli, Pasteurella haemolytica, Pasteurella multocida, Haemophilus Somnus, Actinobacillus pleuropneumonia, Haemophilus parasuis, Salmonella cholerasuis, Streptococcus suis, Streptococcus zooepidemicus, Pasteurella spp , Staphylococcus spp., Actynomyces pyogenes, Salmonella typhimurium, Streptococcus agalactiae, S. dysgalactiae, S. Bovis, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteus spp., Fusobacterium necrophorum and Porphiromonas assacharolytica (Bacteroides melaninogenicus ).
Mode action is suppressing bacterial surface synthesis.
Ketoprofen is NSAID, based on propionic acid. It has anti-inflammatory and antipyretic actions. Mode action connects with synthesis suppressing of prostaglandin at a level of COX. Additionally, ketoprofen inhibits lipoxygenase, has an anti-bradykinin effect, stabilizes lysosomal membranes, causes serious neutrophil suppression activity. Ketoprofen is a double inflammation paralyzer, blocking its COX routes and LOX, preventing the formation of prostaglandins and leukotrienes.
Ketoprofen is an analgetic drug, having an effect CNS and PNS. It imminently suppresses the bradykinin effect, vasodepressor, and pain neuromediators.
parenteral administration, ceftiofur fast absorbs into application places and penetrates into all animal tissues. Its maximum concentration in blood plasma is reached in an hour and lasts on the therapeutic level up to 24 hours, depending on animal type.
Ceftiofur fast metabolizes in the body with desferal-ceftiofur formation, being active as ceftiofur bacteria. This is an active metabolite, binding to plasma proteins and accumulating in the nidus, in this case. Its activity does not reduce even in necrotized tissues.
Drug discharges through urine and fecal masses.
Ketoprofen absorbs fast and binds to plasma proteins. High ketoprofen concentration is in synovia. Here its level is higher than in plasma and during semi- excretion in 2-3 times higher. Ketoprofen metabolizes in the liver to light biologically active metabolites. 90% of the drug discharges through urine as glucuronide compounds.
APPLICATION:
Treatment of cows against necrobacillosis and endometritis, as well as respiratory diseases caused by ceftiofur-sensitive microorganisms.
DOSAGE:
Once a day in a dose of 1 ml per 50 kg BWG.
Course treatment is 3-5 days for respiratory diseases,
3 days for necrobacillosis and 5 days for endometritis.
Before application, bottle must be shaken and heated to 36 ° C.
CONTRAINDICATIONS:
Do not apply to animals with individual hypersensibility to API or additional agents.
Do not mix with another drug into the same syringe.
Do not apply to animals with acute nephratonia.
Do not apply to animals before 6 weeks old.
Do not apply to animals with haemopoiesis disorder, GIT ulceration, liver, and kidney disorders.
Do not apply to animals, suffering from hypotonia, hypovolaemia, and dehydration.
Do not apply at the same time with other NSAIDs, diuretic agents or blood-thinning medication, tetracyclines, chloramphenicol, macrolides, and lincosamides.
Withdrawal period:
Meat consumption -12 days, milk – N/A
Meat and milk, received before the indicated date, must be utilized or fed to non-productive animals, depending on the conclusion of the veterinarian.
Storage:
A dry, dark place, out of the reach of children, at a temperature from 10 ° C to 25 ° C.
After the first taking, the product must be used during the first 7 days, storing in a dry, dark place at a temperature from 4 ° C to 8 ° C.
FOR VETERINARY USE ONLY!