1 ml of product contains API:

ceftiofur HCL – 50 mg;

ketoprofen – 150 mg.


Ceftiofur, a third-generation cephalosporin, effectively combats a broad spectrum of bacteria, including those resistant to beta-lactam antibiotics. It targets both gram-positive and gram-negative bacteria, as well as some anaerobic strains. Its mechanism involves inhibiting bacterial cell wall synthesis.

Ketoprofen, classified as a non-steroidal anti-inflammatory drug (NSAID), functions by inhibiting prostaglandin synthesis at the cyclooxygenase (COX) level, along with suppressing lipoxygenase activity. It also stabilizes lysosomal membranes and suppresses neutrophil activity. Ketoprofen exerts analgesic effects by acting on both the central and peripheral nervous systems, quickly reducing pain and inflammation.

Upon parenteral administration, ceftiofur rapidly absorbs into tissues and achieves peak plasma concentrations within an hour, maintaining therapeutic levels for up to 24 hours. It undergoes metabolism to desfural-ceftiofur, an active metabolite that retains efficacy even in necrotic tissues, before being eliminated via urine and feces.

Ketoprofen demonstrates rapid absorption and high protein binding, with significant accumulation in synovial fluid. Liver metabolism produces biologically active metabolites, with 90% of the drug excreted through urine as glucuronide compounds.


Ceftiofur is applied in the treatment of cows for necrobacillosis, endometritis, and respiratory diseases caused by bacteria susceptible to ceftiofur.


The dosage regimen for ceftiofur in cows is as follows:

  • Administration: Once daily
  • Dosage: 1 ml per 50 kg of Body Weight Gain (BWG)
  • Treatment Duration:
  • Respiratory Diseases: 3-5 days
  • Necrobacillosis: 3 days
  • Endometritis: 5 days

Before application, shake the bottle and heat it to 36°C.


  1. Individual hypersensitivity to the active pharmaceutical ingredient (API) or additional agents.
  2. Mixing with another drug in the same syringe.
  3. Acute nephrotoxicity in animals.
  4. Animals younger than 6 weeks old.
  5. Conditions such as hematopoietic disorders, gastrointestinal ulceration, liver, and kidney disorders.
  6. Animals suffering from hypotonia, hypovolemia, and dehydration.
  7. Concurrent use with other NSAIDs, diuretic agents, blood-thinning medications, tetracyclines, chloramphenicol, macrolides, and lincosamides.

These contraindications should be considered before administering ceftiofur to cows to ensure the safety and effectiveness of treatment.


The withdrawal period for ceftiofur in cows is as follows:

  • Meat Consumption: 12 days
  • Milk: Not Applicable (N/A)

Meat and milk obtained before the withdrawal period must either be consumed or fed to non-productive animals based on the recommendation of a veterinarian.


  • Dry, Dark Place: Store in a dry, dark place.
  • Temperature Range: Keep out of reach of children at temperatures ranging from 10°C to 25°C.
  • After First Use: Once opened, use within the first 7 days.
  • Refrigeration: Store in a dry, dark place at temperatures between 4°C to 8°C after first use.