Cream
DESCRIPTION:
White Cream.
COMPOSITION:
1 g of the drug contains active substances (mg):
Betamethasone dipropionate – 0,64;
Gentamicin sulfate – 1,0;
Clotrimazole – 10,0.
Excipients: – up to 1g
PHARMACOLOGICAL CHARACTERISTICS:
Thanks to a combination of active ingredients this cream has anti-inflammatory, anti-allergic, antibacterial, antifungal actions. Betamethasone dipropionate is a synthetic fluorine-consisting corticosteroid. It has anti-inflammatory, glucocorticoid, antiallergic, antipruritic actions.
In case of external application to narrows blood vessels, it eliminates itching, slows excretion of inflammatory mediators (eosinophils, mast cells), interleukins 1 and 2, γ-interferon (from lymphocytes and macrophages), inhibits the activity of hyaluronidase, and reduces the permeability of vessel walls.
Clotrimazole belongs to the group of imidazole antifungal drugs. Increases the permeability of the phospholipid membrane of liposomes, vacuolization of cytoplasm, reduction of the number of ribosomes. Clotrimazole is active in relation to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum sapis, Candida alvicans, Malassezia furfur (Pityrosporum orbiculare).
Gentamicin is a broad-spectrum antibiotic of the aminoglycoside group that acts bactericidal on gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus Vulgaris, Klebsiella pneumonia; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.
In the case of cutaneous application of the drug Beclogen Cream in therapeutic doses, transdermal absorption of active substances in the blood is very low. Application of occlusive bandages significantly enhances transdermal absorption of gentamicin and betamethasone, which can lead to an increase in the risk of systemic side effects
APPLICATION:
For the treatment of dogs and cats dermatitis with severe allergic, inflammatory reaction, pruritus, hyperemia, edema, infiltration, complicated by secondary bacterial infection; fungal skin diseases caused by Microsporum canis, Trichophyton rubrum, Trichophyton mentagrorhytes, candidiasis caused by Candida albicans, Candida parapsilosis, lesions by yeast fungi Malassezia furfur.
DOSAGE:
Cream use externally, locally.
The dose of the drug depends on the area of the affected skin.
Before applying the cream cut hair on the affected area!
The cream should be applied on the affected skin and surrounding area with a thin layer 2 times a day (morning and evening), gently rubbing into the skin.
After achieving clinical improvement, the frequency of application of the drug can be reduced to 1 time per day.
The duration of treatment is determined by the elimination of inflammation process and negative data of bacterial and/ or mycological analysis, by the termination of itching, skin cleansing.
The course of treatment depends on the type and severity of disease and the effectiveness of therapy and is determined by the doctor of veterinary medicine and usually lasts 2-4 weeks (maximum);
Repeated courses need a necessary break lasting at least 20 days.
CONTRAINDICATIONS:
Hypersensitivity to the components of the drug.
SIDE EFFECTS:
Excessive and prolonged application of the drug on large areas of skin can lead to the appearance of systemic effects inherent for application glucocorticosteroids, namely the inhibition of the hypothalamic-pituitary-adrenal system with the development of secondary adrenal insufficiency, symptoms of hypercorticism (weight gain, edema, hypertension, glycosuria, hypokalemia), the occurrence of Cushing’s syndrome.
PRECAUTIONS:
Avoid getting the drug in the eyes and open wounds.
Do not apply cream on the skin around eyes.
PACKAGING:
Containers polymeric 20 g.
STORAGE.
In original packaging at a temperature not above 25°C.
Do not freeze.
FOR VETERINERY USE ONLY!