K-CLOZAN 50

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COMPOSITION :

1 ml contains: Closantel – 50 mg;

PHARMACOLOGICAL CHARACTERISTICS:

Closantel, the active ingredient, is an antiparasitic agent derived from salicylanilide, with prolonged effects on endo- and ectoparasites. It disrupts the phosphorylation process in parasites, interfering with electron transport and altering energy metabolism, ultimately leading to parasite death. Effective against a wide range of parasitic diseases in cattle and small ruminants caused by nematodes, trematodes, and arthropods. Rapidly absorbed after oral or intramuscular administration, reaching peak blood concentrations in sheep after 8-24 hours and in cattle after 24-48 hours, with a half-life of approximately 12-15 days. Mainly concentrated in the lungs and kidneys, metabolized through renewable deionization.

APPLICATION:

This medication is used for the prevention and treatment of cattle and small ruminants affected by various diseases including fasciolosis, nematodiasis, and oestrosis.

DOSAGE & ADMINISTARTION::

Administered subcutaneously once at recommended doses, with the suggestion to apply the dose in different locations.

  TYPE ANIMALS  DISEASESTHE DOSE BY THE ACTIVE SUBSTANCE  DOSE
  CattleFasciolosis Nematodiasis Hypodermosis2,5 mg closantel per kg of body weight.
2,5 mg closantel per kg of body weight.
5 mg closantel per kg of body weight
0,5 ml/10 kg of body weight.
0,5 ml/10 kg of body weight.
1 ml/10 kg of body weight
  Sheep, goatsFasciolosis Nematodiasis, Oestrosis5 mg closantel per kg of body weight.
2,5 mg closantel per kg of body weight
  1 ml/10 kg of body weight.
0,5 ml/10 kg of body weight

CONTRAINDICATIONS:

Avoid concurrent use with chlorinated antiparasitic products. Not suitable for dairy cows and pregnant females in the last trimester of pregnancy.

PRECAUTIONS:

Meat consumption permissible after 28 days from the last dose, while milk consumption is permissible after 14 days. Minor inflammation at the injection site may occur, typically resolving within 2-3 days. Some cattle breeds, notably Charolais and hybrids, may be sensitive to the drug, with approximately 2% experiencing anaphylactic reactions post-injection.

PACKAGING :

Available in glass bottles of 50, 100, and 250 ml.

STORAGE:

Store in a cool, dry, dark place at temperatures between 5°C to 25°C.