{"id":418,"date":"2020-07-18T10:46:03","date_gmt":"2020-07-18T10:46:03","guid":{"rendered":"https:\/\/knight-pharma.com\/web\/?page_id=418"},"modified":"2024-04-28T23:49:19","modified_gmt":"2024-04-28T23:49:19","slug":"k-clozan-50","status":"publish","type":"page","link":"https:\/\/knight-pharma.com\/web\/k-clozan-50\/","title":{"rendered":"K-CLOZAN 50"},"content":{"rendered":"\n

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COMPOSITION :<\/span> <\/strong><\/p>\n\n\n\n

1 ml contains: Closantel \u2013 50 mg;<\/p>\n\n\n\n

PHARMACOLOGICAL CHARACTERISTICS:<\/span> <\/strong><\/p>\n\n\n\n

Closantel, the active ingredient, is an antiparasitic agent derived from salicylanilide, with prolonged effects on endo- and ectoparasites. It disrupts the phosphorylation process in parasites, interfering with electron transport and altering energy metabolism, ultimately leading to parasite death. Effective against a wide range of parasitic diseases in cattle and small ruminants caused by nematodes, trematodes, and arthropods. Rapidly absorbed after oral or intramuscular administration, reaching peak blood concentrations in sheep after 8-24 hours and in cattle after 24-48 hours, with a half-life of approximately 12-15 days. Mainly concentrated in the lungs and kidneys, metabolized through renewable deionization.<\/p>\n\n\n\n

APPLICATION:<\/span> <\/strong><\/p>\n\n\n\n

This medication is used for the prevention and treatment of cattle and small ruminants affected by various diseases including fasciolosis, nematodiasis, and oestrosis.<\/p>\n\n\n\n

DOSAGE & ADMINISTARTION:<\/strong>:<\/span> <\/strong><\/p>\n\n\n\n

Administered subcutaneously once at recommended doses, with the suggestion to apply the dose in different locations.<\/p>\n\n\n\n

  TYPE ANIMALS<\/span><\/strong><\/td>  DISEASES<\/span><\/strong><\/td>THE DOSE BY<\/strong> THE ACTIVE SUBSTANCE<\/strong><\/span><\/td>  DOSE<\/span><\/strong><\/td><\/tr>
  Cattle<\/td>Fasciolosis Nematodiasis Hypodermosis<\/td>2,5 mg closantel per kg of body weight.
2,5 mg closantel per kg of body weight.
5 mg closantel per kg of body weight<\/td>		0,5 ml\/10 kg of body weight.
0,5 ml\/10 kg of body weight.
1 ml\/10 kg of body weight<\/td><\/tr>
  Sheep, goats<\/td>Fasciolosis Nematodiasis, Oestrosis<\/td>5 mg closantel per kg of body weight.
2,5 mg closantel per kg of body weight<\/td>		  1 ml\/10 kg of body weight.
0,5 ml\/10 kg of body weight<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

CONTRAINDICATIONS<\/strong>:<\/mark> <\/p>\n\n\n\n

Avoid concurrent use with chlorinated antiparasitic products. Not suitable for dairy cows and pregnant females in the last trimester of pregnancy.<\/p>\n\n\n\n

PRECAUTIONS:<\/span> <\/strong><\/p>\n\n\n\n

Meat consumption permissible after 28 days from the last dose, while milk consumption is permissible after 14 days. Minor inflammation at the injection site may occur, typically resolving within 2-3 days. Some cattle breeds, notably Charolais and hybrids, may be sensitive to the drug, with approximately 2% experiencing anaphylactic reactions post-injection.<\/p>\n\n\n\n

PACKAGING :<\/span><\/strong> <\/p>\n\n\n\n

Available in glass bottles of 50, 100, and 250 ml.<\/p>\n\n\n\n

STORAGE:<\/span> <\/strong><\/p>\n\n\n\n

Store in a cool, dry, dark place at temperatures between 5\u00b0C to 25\u00b0C.<\/p>\n\n\n\n

FOR VETERINARY USE ONLY!<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

<<PREVIOUS || NEXT>> COMPOSITION : 1 ml contains: Closantel \u2013 50 mg; PHARMACOLOGICAL CHARACTERISTICS: Closantel, the active ingredient, is an antiparasitic agent derived from salicylanilide, with prolonged effects on endo- and ectoparasites. It disrupts the phosphorylation process in parasites, interfering with electron transport and altering energy metabolism, ultimately leading to …<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-418","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/pages\/418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/comments?post=418"}],"version-history":[{"count":17,"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/pages\/418\/revisions"}],"predecessor-version":[{"id":4828,"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/pages\/418\/revisions\/4828"}],"wp:attachment":[{"href":"https:\/\/knight-pharma.com\/web\/wp-json\/wp\/v2\/media?parent=418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}